Fats are triglycerides that are comprised of fatty acids that vary in chain lengths and also are hydrolyzed and digested differently, depending on that chain length.
While all triglycerides provide caloric benefit, they have different impacts on physiological functions. Both medium-chain triglycerides (MCTs) and long-chain triglycerides (LCTs) provide calories, but LCTS are especially important as a source for long-chain fatty acids. They also provide about 10% more calories than MCTs.
Pancreatic enzymes such as lipase are necessary to break down fats into fatty acids and monoglycerides, and make these calories available to be absorbed by the patient.
Patients who lack the ability to properly hydrolyze fats experience decreased caloric absorption and reduced digestion of fats. Read more on that here.
Read more on RELiZORB, which mimics the function of pancreatic lipase to hydrolyze available fats, including difficult to hydrolyze but important LCTs, from enteral nutrition.