The inability to fully access the caloric density of fats is a challenge for patients relying on enteral nutrition who may lack the inability to properly and effectively hydrolyze available fats.
- Of the digestive enzymes, lipases have the ability to hydrolyze, or digest, fats (amylase acts on starches and protease acts on proteins)
- Further, proteins and starches are digested in multiple parts of the gastrointestinal tract, whereas fats remain mostly unchanged until they reach the small intestine and interact with pancreatic lipase
- Pancreatic lipase accounts for up to 90% of fat digestion
Not all lipases are created equal; certain lipases have the ability to hydrolyze long-chain triglycerides (LCTs), which are difficult to digest.
Like human pancreatic lipase, the lipase in RELiZORB is intended to selectively cleave triglycerides at the sn-1 and sn-3 positions, but without the need for co-lipase. The lipase in RELiZORB has optimal activity at the pH of enteral formulas.
RELiZORB is designed to mimic the function of pancreatic lipase and hydrolyze available fats prior to ingestion of enteral formula.
Check out the data on RELiZORB.