Why RELiZORB?

Patients who rely on enteral nutrition may not be able to properly hydrolyze available fats from enteral formula. RELiZORB is designed to change that. RELiZORB is a first-of-its-kind digestive enzyme cartridge that easily connects in-line to the enteral feeding system. When enteral formula flows through RELiZORB, lipase enzyme contained with the cartridge hydrolyzes available fats to deliver more absorbable calories to the patient.

RELiZORB is a first-of-its-kind digestive enzyme cartridge

  • Designed to address the unmet need of patients on enteral nutrition who cannot properly hydrolyze fats
  • Mimics the function of pancreatic lipase
  • Hydrolyzes available fats in enteral formulas – immediately prior to ingestion
  • Fat hydrolysis occurs ex vivo

When patients do not have the ability to properly hydrolyze available fats from enteral formula, there is incomplete hydrolysis of fats, in particular long-chain triglycerides (LCTs), from enteral feeding, which can lead to:

  • Fewer calories
  • Weight loss
  • Shortage of key fats
  • Lower levels of some vitamins

More About Fat Hydrolysis, Lipase, and Relizorb

The pancreatic enzyme lipase is necessary to break down fats into fatty acids and monoglycerides, and make these calories available to be absorbed by the patient. Read more on fat malabsorption here. 

Lipases have an ability to hydrolyze fats; certain lipases hydrolyze LCTs, which are difficult to digest.

  • Like human pancreatic lipase, the lipase in RELiZORB is intended to selectively cleave triglycerides at the sn-1 and sn-3 positions, but without the need for co-lipase
  • The lipase in RELiZORB has optimal activity at the pH of enteral formulas

Learn more about how RELiZORB works by clicking here. 

Did You Know?

  • Digestion of proteins and starches is not exclusively dependent on enzymes released by the pancreas1 whereas fats remain mostly unchanged until they reach the small intestine and interact with pancreatic lipase

  • Since pancreatic lipase accounts for up to 90% of fat digestion, fat may be the most poorly absorbed macronutrient relative to carbohydrates and proteins

 

1. Tavakkoli A, Ashley SW, Zinner MJ. Small intestines. In: Brunicardi FC, Andersen DK, Billiar TR, eds. Schwartz’s Principles of Surgery. 10th ed. New York, NY: McGraw-Hill; 2015.

About RELiZORB
RELiZORB is a first-of-its-kind digestive enzyme cartridge that easily connects in-line to the enteral feeding system.

RELiZORB is designed to hydrolyze available fats in enteral formulas into fatty acids and monoglycerides, such as omega-3 fats, which are critical for normal growth and development.